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Championship side Sheffield Wednesday name a youthful line up as Cole McGhee and George Brown are handed debuts.
Sixteen-year-old Will Grainger is on the bench.
Sheffield Wednesday XI: Horvarth, Siqueira, McGhee, Weaver, Otegbayo, Johnson, Fusire, Shipston, Thornton, J Lowe, Brown
Subs: Stretch, Palmer, Emery, Evers, Bannan, Grainger, McNeill, Ugbo
Leeds make nine changes from the side that lost 5-0 to Arsenal at the weekend.
Ilia Gruev and Joel Piroe are the only two to retain their place in the 11.
Leeds XI: Darlow, Longstaff, Piroe, Aaronson, Nmecha, Bijol, Okafor, Harrison, Bornauw, Byram, Gruev.
Subs: Perri, Bogle, Gudmundsson, Rodon, James, Calvert-Lewin, Stach, Gnonto, Gray.
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